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ClpP agonist 1

SKU: orb3211240

Description

ClpPagonist 1 is an activator of Staphylococcus aureus ClpP (SaClpP) with an EC50 of 1.44 μM, and Kd values of 2.95 μM (isothermal titration calorimetry) and 18 μM (biolayer interferometry), displaying a low resistance frequency. In a murine skin infection model, ClpPagonist 1 reduces bacterial load, decreases infection size, and improves histopathological outcomes. This compound is applicable for research on Methicillin-resistant Staphylococcus aureus (MRSA) skin infections.

Images & Validation

Key Properties

CAS Number2761081-10-9
MW476.44
FormulaC24H21F5N4O
SMILESO=C1C2=C(N3C(=NCC3)N1CC4=CC=C(C=C4)C(F)(F)F)CCN(CC=5C=C(F)C=C(F)C5)C2
TargetAntibacterial,Protease

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information