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Cot inhibitor-1

SKU: orb1710003

Description

Cot inhibitor-1 is a potent and selective small molecule targeting the Cot/Tpl2 (MAP3K8) kinase, exhibiting an IC50 of 28 nM. It effectively suppresses TNF-α production in human whole blood (IC50 = 5.7 nM), supporting its research utility in studying inflammatory pathways, immune responses, and related conditions such as rheumatoid arthritis and inflammatory bowel disease.

Research Area

Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number915365-57-0
MW553.46
Purity99.19% (May vary between batches)
FormulaC27H27Cl2FN8
SMILESFc1ccc(Nc2c(cnc3c(Cl)cc(NCc4cn(CCN5CCCCCC5)nn4)cc23)C#N)cc1Cl
TargetMAPK,TNF
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.61 mM);DMSO:55 mg/mL (99.37 mM);H2O:0.1 mg/mL (0.18 mM)

Bioactivity

Target IC50
TNF-α:5.7 nM|Tpl2 kinase:28 nM

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

TNF-α, Cot inhibitor 1, Cot inhibitor1, Cot inhibitor-1, MAP3K

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Key Properties

No computed properties available.

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Cot inhibitor-1 (orb1710003)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 120.00
5 mg
$ 220.00
1 ml x 10 mM (in DMSO)
$ 250.00
10 mg
$ 300.00
25 mg
$ 510.00
50 mg
$ 730.00
100 mg
$ 1,090.00
200 mg
$ 1,460.00
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