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CR-6086

SKU: orb1738762

Description

CR6086 is a potent and selective EP4 receptor antagonist with a Ki of 16.6 nM, effectively blocking PGE2-induced cAMP signaling. It demonstrates immunomodulatory and anti-inflammatory properties distinct from COX inhibitors, showing disease-modifying antirheumatic drug (DMARD) effects in rodent models of immune-mediated inflammatory diseases.

Research Area

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery, Protein Biochemistry

Images & Validation

Key Properties

CAS Number1417742-86-9
MW472.5
FormulaC26H27F3N2O3
SMILESN(C(=O)C1N(CC2=CC=C(C(F)(F)F)C=C2)CCC3(C1)CC3)C4(CC4)C5=CC=C(C(O)=O)C=C5
TargetInterleukin,MMP,Others,PD-1/PD-L1,Prostaglandin Receptor

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Key Properties

No computed properties available.

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Protocol Information

CR-6086 (orb1738762)

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