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CU CPT 4a

SKU: orb1218967

Description

CU CPT 4a is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells). It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the production of TNF-α and IL-1β in whole cells.

Images & Validation

Key Properties

CAS Number1279713-77-7
MW377.82
Purity>98% (HPLC)
FormulaC18H13ClFNO3S
SMILESO=C(O)[C@@H](CC1=CC=CC=C1)NC(C2=C(Cl)C3=CC=C(F)C=C3S2)=O
TargetTLR
SolubilityDMSO:<37.78mg/ml

Bioactivity

In Vitro
CU-CPT 4a shows dose-dependent inhibitory effects blocking Poly (I: C)-induced TLR3 activation with an IC50 of 3.44 μM. CU-CPT 4a competes with dsRNA for binding to TLR3 with a Ki of 2.96 μM.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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CU CPT 4a (orb1218967)

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Available Sizes

Select a size below

2 mg
$ 120.00
5 mg
$ 180.00
10 mg
$ 280.00
25 mg
$ 570.00
50 mg
$ 830.00
100 mg
$ 1,170.00
500 mg
$ 2,310.00