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cyclo(CLLFVY)

SKU: orb2645947

Description

Cyclo(CLLFVY) is a cyclic peptide inhibitor of HIF-1 that targets the HIF-1α PAS-B domain, blocking dimerization and downstream gene expression (e.g., VEGF, CAIX) with IC50 values of 19 μM (U2OS) and 16 μM (MCF-7). It is a research tool for studying hypoxia signaling and oncology in cellular models.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Metabolism Research, Signal Transduction

Images & Validation

Key Properties

TargetVEGFR,HIF/HIF Prolyl-Hydroxylase
Molecular Weight738.94

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

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cyclo(CLLFVY) (orb2645947)

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