Cynomolgus IL-23 R Protein

SKU: orb1496206

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Description

Interleukin 23 receptor (IL-23R) is a type I cytokine receptor, and IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. Also, IL-23R associates constitutively with Janus kinase 2 (JAK2), and binds to transcription activator STAT3 in a ligand-dependent manner. Furthermore, IL-23R mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. As for IL-23, it may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.

Images & Validation

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Application Notes	This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 64.5 kDa. The protein migrates as 90-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Key Properties

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Source	Cynomolgus IL-23 R, Fc Tag (orb1496206) is expressed from human 293 cells (HEK293). It contains AA Gly 24 - Asp 353 (Accession # G7NWY5).
Expression System	HEK293
Target	IL-23 R
Reactivity	Monkey
Tag	C-Fc
Molecular Weight	64.5 kDa
Expression Region	Gly 24 - Asp 353
Purity	95%
Endotoxins	1.0 EU per μg

Storage & Handling

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Storage	-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Form/Appearance	Liquid
Buffer/Preservatives	PBS, pH7.4
Dry Ice Shipping	Please note: This product requires shipment on dry ice. A dry ice surcharge will apply.
Disclaimer	For research use only

Alternative Names

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IL-23 R,IL-23 Receptor

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Immobilized Biotinylated Human IL-23A & IL-12B Heterodimer Protein, His, Avitag & Tag Free at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. orb668907) precoated (0.5 μg/well) plate can bind Cynomolgus IL-23 R, Fc Tag (Cat. No. orb1496206) with a linear range of 0.1-3 ng/mL (QC tested).

Quick Database Links

Gene Symbol

IL-23 R

UniProt

G7NWY5

UniProt Details

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No UniProt data available

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