Cynomolgus Integrin alpha X beta 2 (ITGAX&ITGB2) Heterodimer Protein, His Tag&Tag Free

SKU: orb3158175

Description

The integrin αXβ2 takes a key role in host defense and functions as a receptor for the complement C3 cleavage product iC3b, fibrinogen, denatured proteins, and intercellular adhesion molecule (ICAM)-1. Integrin αXβ2 αXβ2 has a unique cellular distribution with expression on monocytes, macrophages, and the CD8− subsets of dendritic cells and involves in priming and regulation of the immune response.

Images & Validation

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Application Notes

Cynomolgus ITGAX&ITGB2 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGAX and ITGB2, has a calculated MW of 125.9 kDa (ITGAX) and 78.0 kDa (ITGB2). Subunit ITGAX is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB2 contains no tag but a basic tail at the C-terminus. The protein migrates as 150-180 kDa (ITGAX) and 95-100 kDa (ITGB2) when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Key Properties

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Expression System	HEK293
Target	Integrin alpha X beta 2
Reactivity	Monkey
Tag	C-10×His \| Native
Molecular Weight	125.9 kDa \| 78.0 kDa
Expression Region	Phe 20 -Pro 1107 (ITGAX) & Gln 23 - Asn 700 (ITGB2)
Purity	90%
Endotoxins	1.0 EU per μg
Conjugation	Unconjugated

Storage & Handling

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Storage	-20°C
Form/Appearance	Powder
Buffer/Preservatives	50 mM Tris, 150 mM NaCl, pH 7.5
Expiration Date	6 months from date of receipt.
Disclaimer	For research use only

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Quick Database Links

Gene Symbol

Integrin alpha X beta 2

RefSeq:ITGB2, XP_065397351.1, XP_015298151.3

NCBI Reference Sequences

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Associated Accession Numbers

Curated reference sequences for the gene transcript and protein product

RefSeq	ITGB2, XP_065397351.1, XP_015298151.3

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