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Cynomolgus Kallikrein 3 Protein, His Tag (active enzyme, MALS verified)

SKU: orb3158180

Description

Kallikrein-related peptidase 3, more commonly known as Kallikrein 3 (KLK3) or Prostate-Specific Antigen (PSA), is a serine protease belonging to the kallikrein family. Its primary function is to cleave proteins, and it is a key biomarker for prostate cancer. Secreted by the epithelial cells of the prostate gland, elevated levels of KLK3 in the blood are often indicative of prostate pathologies, including benign prostatic hyperplasia and prostate cancer. Beyond its role as a diagnostic marker, recent research explores its potential as a therapeutic target in cancer treatment. Its unique expression pattern and enzymatic function make it a subject of extensive research in oncology.

Images & Validation

Application Notes
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 28.7 kDa. The protein migrates as 30-35 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Key Properties

Expression SystemHEK293
TargetKallikrein 3
ReactivityMonkey
TagC-10×His
Molecular Weight28.7 kDa
Expression RegionPro 19 - Pro 261
Purity95%
Endotoxins1.0 EU per μg
ConjugationUnconjugated

Storage & Handling

Storage-20°C
Form/AppearancePowder
Buffer/Preservatives50 mM Tris, 150 mM NaCl, pH 7.5
Expiration Date6 months from date of receipt.
DisclaimerFor research use only
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NCBI Reference Sequences

Associated Accession Numbers
Curated reference sequences for the gene transcript and protein product
RefSeqQ6DT45

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Protocol Information

Cynomolgus Kallikrein 3 Protein, His Tag (active enzyme, MALS verified) (orb3158180)

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100 μg
$ 730.00
1 mg
$ 4,470.00
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