Cynomolgus Kallikrein 5 Protein, His Tag (active enzyme, HPLC verified)

SKU: orb3158178

Description

Kallikrein‑related peptidase 5 (KLK5) is a secreted serine protease encoded by the KLK5 gene on chromosome 19q13.4. It is synthesized as an inactive zymogen and activated extracellularly, where it participates in proteolytic cascades with other kallikreins. KLK5 is highly expressed in the skin, particularly in the stratum corneum, where it regulates desquamation by cleaving corneodesmosomal proteins. Dysregulated KLK5 activity contributes to impaired barrier function and inflammatory skin disorders such as Netherton syndrome, atopic dermatitis, and rosacea. Beyond dermatology, KLK5 has been implicated in cancer biology, extracellular matrix remodeling, and as a potential biomarker and therapeutic target.

Images & Validation

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Application Notes	This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.9 kDa. The protein migrates as 33-43 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Key Properties

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Expression System	HEK293
Target	Kallikrein 5
Reactivity	Monkey
Tag	C-10×His
Molecular Weight	26.9 kDa
Expression Region	Ile 65 - Ser 291
Purity	95%
Endotoxins	1.0 EU per μg
Conjugation	Unconjugated

Storage & Handling

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Storage	-20°C
Form/Appearance	Powder
Buffer/Preservatives	50 mM Tris, 150 mM NaCl, pH 7.5
Expiration Date	6 months from date of receipt.
Disclaimer	For research use only

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Quick Database Links

Gene Symbol

Kallikrein 5

RefSeq:XP_005590111.3

NCBI Reference Sequences

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Associated Accession Numbers

Curated reference sequences for the gene transcript and protein product

RefSeq	XP_005590111.3

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