CYP51/PD-L1-IN-1

CYP51/PD-L1-IN-1 (L11) is a dual-target quinazoline inhibitor of fungal CYP51 and host PD-L1, exhibiting potent in vitro antifungal activity. Its mechanism involves inducing fungal apoptosis via mitochondrial dysfunction, ROS generation, and suppression of key inflammatory mediators like IL-2, NLRP3, and NF-κB, leading to cell lysis. This profile makes it a candidate for research in immunomodulatory antifungal therapies.