Cysteamine hydrochloride

SKU: orb1300749

Description

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	156-57-0
MW	113.61
Purity	99.87%
Formula	C₂H₇NS·HCl
SMILES	Cl.NCCS
Target	Endogenous Metabolite,Autophagy,Reactive Oxygen Species,Apoptosis
Solubility	DMSO:71.43 mg/mL (628.73 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (17.6 mM);Ethanol:22 mg/mL (193.64 mM);H2O:21 mg/mL (184.84 mM)

Bioactivity

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In Vivo

Cysteamine is introduced as a treatment for cystinosis by depleting lysosomal cystine. Cystamine can inhibit transglutaminase activity by binding to the cysteine in its active center. Cysteamine increases brain levels of brain-derived neurotrophic factor (BDNF), which is caused by the increased expression of the heat shock DNAJ-containing protein 1 (HSJ1). Cysteamine inhibits the formation of gastric and mammary tumors that are induced chemically or after irradiation, respectively. The administration of Cysteamine is also able to inhibit the metastasis of pancreatic cancer in a mouse model by decreasing the expression and activity of metalloproteinases.

In Vitro

Cysteamine enhances intracellular glutathione (GSH) levels in cystinotic cells, effectively restoring their altered redox state and demonstrating antioxidant capabilities by increasing glutathione production, thus scavenging harmful OH and HOCl. It also mitigates increased apoptosis rates in cystinotic cells by counteracting the effects of elevated caspase 3 and protein kinase Cε activity. Furthermore, Cysteamine boosts the production of various heat shock proteins (HSP), notably murine Hsp40. It exhibits a dose-dependent mitigation of doxorubicin-induced death in cancer cells, including HeLa and B16 cells, without affecting cell survival on its own. Remarkably, it enhances the efficacy of doxorubicin in doxorubicin-resistant breast cancer cells, significantly increasing cell death. Additionally, Cysteamine (100 μM) not only heightens intracellular GSH levels but also improves the development of matured oocytes to the blastocyst stage in embryo cultures.

Storage & Handling

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Storage	store under nitrogen \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Cysteamine, Cysteamine HCl, Cysteamine hydrochloride, Cysteamine Hydrochloride, cystinosis, EndogenousMetabolite, Endogenous Metabolite, 2-Mercaptoethylamine, 2-Mercaptoethylamine Hydrochloride, 2-Aminoethanethiol, 2-Aminoethanethiol Hydrochloride, antioxidant, Apoptosis, Autophagy, b-Mercaptoethylamine Hydrochloride, beta-Mercaptoethylamine Hydrochloride, Bekaptan, nephropathic, orally, inhibit, Inhibitor, β-Mercaptoethylamine Hydrochloride, ReactiveOxygenSpecies, Reactive Oxygen Species, Thioethanolamine Hydrochloride

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Compound Identifiers

PubChem CID

9082 ↗

Key Properties

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No computed properties available.

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