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Cytosporone B

SKU: orb1303487

Description

Cytosporone B (Dothiorelone G) is a potent natural agonist of the orphan nuclear receptor Nur77/NR4A1, exhibiting an EC50 of 0.278 nM. This small molecule is a valuable research tool for investigating Nur77's role in apoptosis, metabolism, and inflammation in both cellular and animal models.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number321661-62-5
MW322.4
Purity99.72% (May vary between batches)
FormulaC18H26O5
SMILESCCCCCCCC(=O)c1c(O)cc(O)cc1CC(=O)OCC
TargetOthers,NR4A
SolubilityDMSO:125 mg/mL (387.72 mM);2% DMSO+98% (20% SBE-β-CD in Saline):2 mg/mL (6.2 mM)

Bioactivity

Target IC50
Nur77:0.278 nM
In Vivo
In wild-type mice, Cytosporone B treatment significantly increased glucose levels from 3.2 mM to 11.4 mM within the first 30 minutes, after which blood glucose gradually decreased, reaching initial levels after 300 minutes.
In Vitro
Cytosporone B targets the ligand-binding domain of Nur77, Cytosporone B induced fluorokinase activity in cells cotransfected with GAL4-Nur77 or GAL4-LBD, the EC50 of Cytosporone B for Nur77 is 0.278 nM. Cytosporone B had an inhibitory effect on the proliferation of human cancer BGC- 823 cells and human cancer SW620 cells by greater than 70%, but had modest inhibitory effect on human cancer H1299 cells and human hepatocellular carcinoma HepG2 cells by greater than or equal to 40%.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Dothiorelone G, Csn-B, Cytosporone B, inhibit, Nur77, Inhibitor

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    321661-62-5

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    C18H26O5

    5 mg, 10 mg, 50 mg, 2 mg, 1 g, 500 mg, 100 mg, 25 mg
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Key Properties

No computed properties available.

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Protocol Information

Cytosporone B (orb1303487)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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2 mg
$ 80.00
5 mg
$ 100.00
1 ml x 10 mM (in DMSO)
$ 120.00
10 mg
$ 140.00
25 mg
$ 240.00
50 mg
$ 360.00
100 mg
$ 510.00
500 mg
$ 1,090.00
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