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D4476

SKU: orb1225383

Description

D4476 (Casein Kinase I Inhibitor, D 4476, D-4476) is a potent, selective ATP-competitive inhibitor of CK1 with IC50 of 0.3 uM in vitro; slightly weaker for ALK5 inhibition (IC50=0.5 uM); weak activity for p38α MAPK and no activity for PKB, SGK; specifically inhibits the phosphorylation of endogenous FOXO1a on Ser322 and Ser325; more potent and specific than IC261 or CKI-7.

Images & Validation

Key Properties

CAS Number301836-43-1
MW398.414
Purity>98% (HPLC)
FormulaC23H18N4O3
SMILESO=C(N)C1=CC=C(C2=NC(C3=CC=C(OCCO4)C4=C3)=C(C5=NC=CC=C5)N2)C=C1
TargetCasein Kinase
Solubility10 mM in DMSO

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Casein Kinase I Inhibitor | D 4476 | D-4476

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  • D4476 [orb1305469]

    99.96%

    301836-43-1

    398.41

    C23H18N4O3

    2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 ml x 10 mM (in DMSO)
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Protocol Information

D4476 (orb1225383)

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Available Sizes

Select a size below

2 mg
$ 100.00
5 mg
$ 120.00
10 mg
$ 140.00
25 mg
$ 240.00
50 mg
$ 340.00
100 mg
$ 580.00
500 mg
$ 1,290.00