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Davalintide

SKU: orb3180345

Description

Davalintide is an Amylin-mimetic peptide known for its high potency and extended action. It is a highly effective agonist of the amylin receptor (IC50 = 0.04 nM), calcitonin receptor (IC50 = 0.06 nM), and calcitonin gene-related peptide receptor [CGRP receptor] (IC50 = 3.1 nM). Davalintide demonstrates greater efficacy than Amylin in cyclic adenosine monophosphate production through calcitonin receptor activation (EC50 = 1.4 nM). It modulates blood glucose and body weight through mechanisms such as delaying gastric emptying, inhibiting glucagon secretion, and reducing food intake. Davalintide is utilized in research related to anti-obesity and antidiabetic treatments.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

TargetAmylin Receptor,CGRP Receptor
CAS Number863919-85-1
MW3624.08
FormulaC152H248N50O49S2
SMILESC([C@H](CC1=CC=C(O)C=C1)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CN=CN2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC(=O)[C@H]3NC(=O)[C@]([C@@H](C)O)(NC(=O)[C@H](C)NC(=O)[C@]([C@@H](C)O)(NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC([C@H](CCCCN)N)=O)CSSC3)[H])[H])[C@H](C)C)=O)CC(C)C)=O)=O)CCCNC(=N)N)=O)CC(C)C)=O)CO)=O)CCC(N)=O)=O)CCC(O)=O)=O)CC(C)C)=O)=O)CCCNC(=N)N)=O)CC(C)C)=O)CCC(N)=O)=O)[C@@H](C)O)=O)(=O)N4[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC5=CC=C(O)C=C5)C(N)=O)=O)[C@@H](C)O)=O)CC(N)=O)=O)CO)=O)=O)[C@@H](C)O)=O)CC(N)=O)=O)[C@@H](C)O)=O)CCCNC(=N)N)=O)CCC4

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
Quality Guarantee

Quality Guarantee

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Protocol Information

Protein Handling and Storage Guide
Protein Handling Guide
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