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DC-PGKI

SKU: orb3174338

Description

DC-PGKI is an orally active ATP-competitive inhibitor of PGK1, with an IC50 of 0.16 μM and a Kd of 99.08 nM. It stabilizes PGK1 both in vitro and in vivo, inhibiting glycolytic activity and PGK1's kinase function. This inhibition induces the accumulation of NRF2 (nuclear factor erythroid 2-related factor 2, NFE2L2), which then translocates to the nucleus, binds to the proximal regions of IL-1β and IL-6 genes, and inhibits their LPS-induced expression. DC-PGKI is applicable for research in colitis.

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Key Properties

CAS Number2829198-49-2
MW558.46
FormulaC26H29Cl2N7O3
SMILESO=C(OCC)C1=NC=2C=C(Cl)C(Cl)=CC2N=C1N3CCN(C(=O)NC4=CC=C(C=C4)N5CCNCC5)CC3
TargetInterleukin,Nrf2,PGK1

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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DC-PGKI (orb3174338)

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