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DDO-5936

SKU: orb1218351

Description

DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.

Images & Validation

Key Properties

CAS Number2355377-13-6
MW495.59
Purity>98% (HPLC)
FormulaC25H29N5O4S
SMILESO=C(O)CN(C1=CC=C(NC2=NC(N3CCCC3)=NC=C2)C=C1)S(=O)(C4=C(C)C=C(C)C=C4C)=O
TargetHSP
SolubilityIn Vitro: DMSO : 12.5 mg/mL (25.22 mM)

Bioactivity

In Vivo
DDO-5936 (0~80 mg/kg; p.o.) shows effect at the high dose group. DDO-5936 is well tolerated for the absence of serious weight loss. DDO-5936 high dose groups show that tumor cells in the xenografts decreased significantly. DDO-5936 shows limited oral efficiency. Animal model: Mice. Dosage: 0~80 mg/kg. Administration: p.o. Result: Showed a moderate effect at the high dose group.
In Vitro
DDO-5936 is a Hsp90-Cdc37 PPI inhibitor with potency and specificity through binding to a critical site on Hsp90 involving Glu47.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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  • DDO-5936 [orb1298287]

    99.69%

    2355377-13-6

    495.59

    C25H29N5O4S

    1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 ml x 10 mM (in DMSO), 200 mg
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DDO-5936 (orb1218351)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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Available Sizes

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200 mg
500 mg
5 mg
$ 190.00
10 mg
$ 300.00
25 mg
$ 620.00
50 mg
$ 900.00
100 mg
$ 1,270.00