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Decernotinib

SKU: orb1223557

Description

Decernotinib (VX-509, VRT-831509) is a potent, selective, orally available JAK3 inhibitor with Ki of 2.5 nM and cellular IC50 of 50-170 nM, demonstrates limited inhibition of JAK1/JAK2/TYK2 in cell-based assays (25-100 fold); also inhibits JAK1, JAK2 and TYK2 (Ki=11, 13 and 11 nM) in biochemical assay and shows >400-fold selectivity over a broad kinases; inhibits IL-2–induced STAT-5 phosphorylation in IL-2–dependent T-cell line with IC50 of 99 nM, potently suppresses T-cell proliferation with IC50 of 170 nM; modulates proinflammatory response in models of immune-mediated diseases, such as collagen-induced arthritis and delayed-type hypersensitivity.Rheumatoid Arthritis Phase 2 Discontinued.

Images & Validation

Key Properties

CAS Number944842-54-0
MW392.3783
Purity>98% (HPLC)
FormulaC18H19F3N6O
SMILESCC[C@](NC1=NC(C2=CNC3=NC=CC=C32)=NC=C1)(C)C(NCC(F)(F)F)=O.
TargetJAK
Solubility10 mM in DMSO

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

VX-509 | VRT-831509

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  • Decernotinib [orb1305235]

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    944842-54-0

    392.38

    C18H19F3N6O

    2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 mg, 1 ml x 10 mM (in DMSO)
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Decernotinib (orb1223557)

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Available Sizes

Select a size below

2 mg
$ 110.00
5 mg
$ 160.00
10 mg
$ 210.00
25 mg
$ 380.00
50 mg
$ 660.00
100 mg
$ 910.00
500 mg
$ 1,850.00