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Decursin

SKU: orb1221994

Description

Decursin is a phytochemical originally isolated from A. gigas with diverse biological activities. It reduces the growth of B16/F10 murine melanoma cells, via induction of apoptosis and increased caspase-3 activity.

Images & Validation

Key Properties

CAS Number5928-25-6
MW328.36
Purity>98% (HPLC)
FormulaC19H20O5
SMILESCC(=CC(=O)OC1CC2=C(C=C3C(=C2)C=CC(=O)O3)OC1(C)C)C
TargetPKCα
SolubilityDMSO : 125 mg/mL 380.68 mM;

Bioactivity

In Vivo
Animal model: C57BL/6J mice (LLC cells). Dosage: 4 mg/kg. Administration: S. c. ; daily for 4 weeks. Result: Delayed tumor formation and dramatically decreased tumor growth by inhibition of angiogenesis through VEGFR-2 signaling pathway. Animal model: Eight-week-old adult C57BL/6J male and female mice. Dosage: 50 mg/kg. Administration: Intrathecal injection; three times at 2-day intervals, for 6 days. Result: Demonstrated the analgesic ability in In vivo model of paclitaxel-induced peripheral neuropathy.
In Vitro
Cell Viability Assay Cell line: DU145 cells. Concentration: 0, 25, 50, 100 μM. Incubation time: 24, 28, 72, 96 h. Result: Showed a dose- and time- dependent inhibition cell growth with 22% to 51%, 21%to 68%, 9% to 72%, 42% to 90% growth inhibition after 24, 48, 72, and 96 hours oftreatment, respectively. And caused 15%-45% cell death. Cell Cycle Analysis Cell line: DU145 cells. Concentration: 0, 25, 50, 100 μM. Incubation time: 12-96 h. Result: Caused 52%, 65%, and 78% DU145 cells in G1phase. Western blot analysis. Cell line: DU145 cells. Concentration: 0, 25, 50, 100 μM. Incubation time: 24, 48 h. Result: Did not show any any alteration inprotein levels of CDK2, CDK4, CDK6, cyclin D1, and cyclin E, but dose-dependent decreased in the expression of these proteins except cyclin E at 48 h.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Decursin

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  • Decursin [orb1303393]

    99.91%

    5928-25-6

    328.36

    C19H20O5

    1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg, 1 ml x 10 mM (in DMSO)
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Decursin (orb1221994)

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Available Sizes

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5 mg
$ 130.00
10 mg
$ 170.00
25 mg
$ 350.00
50 mg
$ 600.00
100 mg
$ 840.00
500 mg
$ 1,690.00