Dehydroabietinol

SKU: orb1984207

Description

Dehydroabietinol (Pomiferin A) is a bioactive small molecule that demonstrates antimalarial activity against both chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum strains in vitro, with an IC50 of approximately 26-27 µM. This compound is a candidate for research in parasitology and antimalarial drug discovery, exploring mechanisms of action and potential in vivo efficacy.

Research Area

Cardiovascular Research, Infectious Disease & Virology, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	3772-55-2
MW	286.45
Purity	99.83% (May vary between batches)
Formula	C₂₀H₃₀O
SMILES	C[C@@]12C=3C(CC[C@]1([C@@](CO)(C)CCC2)[H])=CC(C(C)C)=CC3
Target	Syk,Antifection

Bioactivity

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In Vitro

Dehydroabietinol isolated from Hyptis suaveolens (L.) Poit. was found to inhibit growth of chloroquine-sensitive as well as chloroquine-resistant strains of Plasmodium falciparum cultivated in erythrocytes in vitro (IC 50 26-27 microM). However, erythrocytes exposed to Dehydroabietinol were transformed in a dose-dependent manner towards spherostomatocytic forms with concomitant formation of endovesicles, as disclosed by transmission electron microscopy. The erythrocyte shape alterations caused by Dehydroabietinol correlated well with its apparent IC 50 value. CONCLUSIONS: Thus, Dehydroabietinol incorporates into the erythrocyte membrane, and since invasion and survival of Plasmodium parasites is known to depend on the function of the erythrocyte membrane, the observed antiplasmodial effect of Dehydroabietinol is presumably an indirect effect on the host cell. Because of these findings, microscopic investigations should be generally used to support claims of antimalarial effects of apolar natural products.

Storage & Handling

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Storage	store at low temperature \| Pure form: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Dehydroabietinol, Dehydroabietyl alcohol, Antifection, Pomiferin A

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Compound Identifiers

PubChem CID

15586718 ↗

Key Properties

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No computed properties available.

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