Demethylisoencecalin

SKU: orb1296960

Description

Demethylisoencecalin (6-Acetyl-5-hydroxy-2,2-dimethyl-2H-1-benzopyran) is a natural product exhibiting anti-hyperglycemic properties. It is a research compound used in metabolic disorder studies, with investigations into its mechanisms conducted in both in vitro assays and in vivo models of diabetes.

Research Area

Metabolism Research

Images & Validation

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Key Properties

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CAS Number	24672-84-2
MW	218.25
Purity	99.89%
Formula	C₁₃H₁₄O₃
SMILES	OC1=C2C(OC(C)(C)C=C2)=CC=C1C(C)=O
Target	Glucosidase,glycosidase,Others
Solubility	DMSO:60 mg/mL (274.91 mM)

Bioactivity

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In Vitro

Demethylisoencecalin (1) and caleins A (4) and C (5) (3.16–31.6 mg/kg, p.o.), the major components from an infusion of Calea ternifolia controlled postprandial glucose levels during an oral sucrose tolerance test (OSTT, 3 g/kg) in normal and nicotinamide/streptozotocin (NA/STZ, 40/100 mg/kg) hyperglicemic mice. The effects were comparable to those of acarbose (5 mg/kg). During the isolation of 1, 4, and 5, four additional metabolites not previously reported for the plant, were obtained, namely 6-acetyl-5-hydroxy-2-methyl-2-hydroxymethyl-2H-chromene (3), herniarin (6), scoparone (7), and 4′,7-dimethylapigenin (8). In addition, the structure of calein C (5) was confirmed by X-ray analysis. Pharmacological evaluation of the essential oil of the species (31.6–316.2 mg/kg, p.o.) provoked also an important decrement of blood glucose levels during an OSTT.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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6-Acetyl-5-hydroxy-2,2-dimethyl-2H-1-benzopyran, Demethylisoencecalin

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Compound Identifiers

PubChem CID

827487 ↗

Key Properties

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No computed properties available.

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