Demethylwedelolactone

SKU: orb1219359

Description

Demethylwedelolactone is a natural product isolated from Eclipta alba, has trypsin inhibitory effect an IC50 of 3.0 μM. it exerts anti-invasive growth effect on breast cancer cells.demethylwedelolactone (DWEL) inhibited the anchorage-independent growth and also suppressed cell motility and cell invasion of MDA-MB-231 cells.DWEL reduced the activity and expression of matrix metalloproteinases (MMPs) involved in blocking the IκB-α/NFκB and MEK/ERK signaling pathways in MDA-MB-231 cells. Furthermore, DWEL suppressed the metastasis and lung colonization of the tumor cells in the nude mice. DWEL derivatives exert anti-invasive growth effect on breast cancer cells.

Images & Validation

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Key Properties

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CAS Number	6468-55-9
MW	300.22
Purity	>98% (HPLC)
Formula	C₁₅H₈O₇
SMILES	O=C1C2=C(OC3=CC(O)=C(O)C=C32)C4=C(O)C=C(O)C=C4O1
Target	Serine Protease
Solubility	In Vitro: DMSO : 100 mg/mL (333.09 mM)

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

Serine Protease

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