Dersalazine Free Base

SKU: orb1739396

Description

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	188913-58-8
MW	600.67
Purity	99.85%
Formula	C₃₅H₃₂N₆O₄
SMILES	C(N1C=2C(N=C1C)=CN=CC2)C3CCN(C(/C=C(\C4=CC=C(N=NC5=CC(C(O)=O)=C(O)C=C5)C=C4)/C6=CC=CC=C6)=O)CC3
Target	PAFR,Platelet aggregation,IL Receptor
Solubility	DMSO:< 1 mg/mL (insoluble or slightly soluble);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

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In Vivo

Dersalazine sodium (DS) (10 or 30 mg/kg; b.i.d.; rats), when administered for 7 days, showed intestinal anti-inflammatory effects in TNBS-induced colitis; these effects were observed both macroscopically and through the profile of inflammatory mediators (TNF, IL-1β, IL-6, and IL-17). Although the 2 day treatment with DS did not induce intestinal anti-inflammatory effects, it was sufficient to reduce the enhanced IL-17 expression. DS showed beneficial effects on DSS-induced colitis in C57BL/6 mice and reduced colonic pro-inflammatory cytokines IL-1β, IL-6, and IL-17.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Plateletaggregation, Platelet aggregation, platelet-activating factor (PAF), IL Receptor, ILReceptor, IL-17A, Dersalazine, Dersalazine Free Base

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Compound Identifiers

PubChem CID

135484128 ↗

Key Properties

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No computed properties available.

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