Deschloroclozapine

SKU: orb1309748

Description

Deschloroclozapine, a Clozapine metabolite, is a potent and selective agonist for chemogenetic DREADDs (hM3Dq & hM4Di), with binding affinities (Ki) of 6.3 and 4.2 nM respectively. It is a key research tool for precise neuronal modulation in vivo and in vitro for neuroscience and behavioral studies.

Research Area

Neuroscience

Images & Validation

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Key Properties

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CAS Number	1977-07-7
MW	292.38
Purity	99.98%
Formula	C₁₈H₂₀N₄
SMILES	CN1CCN(CC1)C1=Nc2ccccc2Nc2ccccc12
Target	Serotonin Transporter,AChR
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (13.68 mM);DMSO:127.5 mg/mL (436.08 mM)

Storage & Handling

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Storage	store at low temperature,keep away from direct sunlight,store under nitrogen \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Disclaimer	For research use only

Alternative Names

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Dopamne D1, Dopamne D2, Dopamne D4, DREADDs, Deschloroclozapine, Muscarinic acetylcholine receptor, muscarinic-based, inhibit, Inhibitor, mAChR, hM3Dq, hM4Di, Serotonin S2A, Serotonin S2C, Serotonin S3, Serotonin Transporter, SerotoninTransporter, serotonin

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Gene Symbol

Serotonin Transporter,AChR

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