Deucravacitinib

SKU: orb1308545

Description

Deucravacitinib

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Immunology & Inflammation, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

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Key Properties

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CAS Number	1609392-27-9
MW	425.46
Purity	99.42%
Formula	C₂₀H₁₉D₃N₈O₃
SMILES	[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncn(C)n2)c1OC
Target	Tyrosine Kinases,Interleukin,IFNAR,JAK
Solubility	10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (7.76 mM);DMSO:84.2 mg/mL (197.9 mM)

Bioactivity

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Target IC50	IL-12:2–19 nM\|Tyk2 JH2:0.2 nM\|IFN-α:2–19 nM\|IL-23:2–19 nM\|JAK1 JH2:1 nM
In Vivo	METHODS: When mirdametinib was used in combination with Deucravacitinib (BMS-986165) (40 μM) in JW23. Cells, cell growth was observed. Results Both drugs synergistically inhibited cell proliferation and increased cell apoptosis compared to either drug alone. Read more...
In Vitro	METHODS the mean daily percent Inhibition of TYK2 was simulated by Deucravacitinib (BMS-986165) (6 mg/12 mg once daily) at clinically relevant concentration . Results Deucravacitinib (BMS-986165) had minimal effects on IL-2-induced STAT5 phosphorylation (JAK 1/3) and TPO-induced STAT3 phosphorylation (JAK 2/2). Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Disclaimer	For research use only

Alternative Names

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Deucravacitinib, BMS 986165, BMS986165, BMS-986165, IFNAR, Inhibitor, Interleukin Related, Interleukin, Interferon-α/β receptor, Interferon-alpha/beta receptor, Janus kinase, JAK1-JH2, JAK1 JH2, JAK, inhibit, Tyk2 JH2, TyrosineKinases, Tyrosine Kinases

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Compound Identifiers

PubChem CID

134821691 ↗

Key Properties

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No computed properties available.

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