Dexamethasone acetate

SKU: orb1310143

Description

Dexamethasone acetate is the acetate salt of the potent synthetic glucocorticoid dexamethasone. It is widely used in research for its anti-inflammatory and immunosuppressive effects, both in vitro and in vivo, by antagonizing NF-κB and modulating apoptotic pathways without significant mineralocorticoid activity.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	1177-87-3
MW	434.50
Purity	99.65% (May vary between batches)
Formula	C₂₄H₃₁FO₆
SMILES	[H][C@@]12C[C@@H](C)[C@](O)(C(=O)COC(C)=O)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C
Target	Annexin A,Antibacterial,NOS,Glucocorticoid Receptor,IL Receptor,Mitophagy,ADC Cytotoxin,Complement System,Antibiotic,Autophagy,SARS-CoV
Solubility	Ethanol:16 mg/mL (36.82 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.6 mM);DMSO:60 mg/mL (138.09 mM)

Bioactivity

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In Vivo

Dexamethasone (2 mg/kg) reduces the number of the BrdU-labeled hepatocytes by 80% in male Fischer F344 rats. Dexamethasone (2 mg/kg) pretreatment suppresses the expression of both TNF and IL-6 after partial hepatectomy and significantly reduces the proliferative response of the hepatocytes in male Fischer F344 rats. Dexamethasone also severely diminishes the induction and expansion of oval cells induced by the 2-acetylaminofluorene/partial hepatectomy (AAF/PH) protocol but does not have any effect on the proliferation of the bile duct cells stimulated by bile duct ligation. Dexamethasone (100 μg/kg) produces a significant decrease 59.2% of BrdU(+) hippocampal progenitor cells in Sprague–Dawley rats. Dexamethasone (100 μg/kg) decreases ERK activation in granule cell layer in Sprague–Dawley rats.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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protein-1, Mitophagy, nuclear, Mitochondrial Autophagy, NSC39471, NSC-39471, NSC 39471, key, lipopolysaccharide, inhibit, Inhibitor, inflammation, ILReceptor, IL Receptor, IL receptor, genes, iNOS, Hexadecadrol, factor-AT, factor-kB, GlucocorticoidReceptor, Glucocorticoid Receptor, Dexamethason Acetate, Dexamethason acetate, Dexamethasone, Dexamethasone 17-acetate, Dexamethasone 21-acetate, Dexamethasone Acetate, Dexamethasone acetate, Bacterial, Autophagy, AnnexinA, Annexin A, Annexin A1, (LPS)-induced

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Compound Identifiers

PubChem CID

236702 ↗

Key Properties

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No computed properties available.

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