Dexamethasone Phosphate disodium

SKU: orb1310142

Description

Research Area

Metabolism Research

Images & Validation

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Key Properties

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CAS Number	2392-39-4
MW	516.4
Purity	99.85%
Formula	C₂₂H₂₈FNa₂O₈P
SMILES	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(COP([O-])([O-])=O)=O)O)C)O)F)C)=O.[Na+].[Na+]
Target	Glucocorticoid Receptor
Solubility	H2O:128.75 mg/mL (249.32 mM);DMSO:1 mg/mL (1.94 mM)

Bioactivity

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In Vivo

Administering Dexamethasone at 2×5 mg/kg effectively reduces lipopolysaccharide (LPS)-induced inflammation. This treatment, particularly a single 10 mg/kg dose (i.p.), significantly lessens granulocyte mobilization and the spontaneous production of oxygen radicals in comparison to animals exposed to LPS and treated with saline. These benefits are pronounced when Dexamethasone is given both 1 hour before and after LPS inhalation, with granulocyte numbers in BALF dropping to those seen in healthy animals (exposed to an aerosol of water). However, rats receiving Dexamethasone show reduced food consumption and weight compared to control rats, and exhibit lower weights even compared to pair-fed rats with similar food intakes. Continuous Dexamethasone treatment for five days results in notable liver enlargement (+42%) and an increased liver-to-body weight ratio (+65%), while the gastrocnemius muscle's wet weight diminishes by 20% without affecting the muscle to body weight ratio (g/100 g body weight), suggesting muscle weight reduction aligns with overall body weight loss.

In Vitro

Dexamethasone regulates multiple transcription factors, including activator protein-1, nuclear factor-AT, and nuclear factor-kB, resulting in the activation and repression of key genes involved in the inflammatory response. Dexamethasone potently inhibits granulocyte-macrophage colony stimulating factor (GM-CSF) release from A549 cells with EC50 of 2.2 nM. Dexamethasone (EC50=36 nM) induces transcription of the β2-receptor is found to correlate with glucocorticoid receptor (GR) DNA binding and occurred at 10-100 fold higher concentrations than the inhibition of GM-CSF release. Dexamethasone (IC50=0.5 nM) inhibits a 3×κB (NF-κB, IκBα, and I-κBβ), which is associated with inhibition of GM-CSF release.

Storage & Handling

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Storage	keep away from direct sunlight,keep away from moisture,store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Dexamethasone Phosphate, Dexamethasone 21-phosphate disodium, Dexamethasone Phosphate disodium, Dexamethasone Sodium Phosphate, 55203-24-2, EGP437, EGP437. Dex-Phos, GlucocorticoidReceptor, Glucocorticoid Receptor

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Compound Identifiers

PubChem CID

16961 ↗

Key Properties

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No computed properties available.

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