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DFCI-002-06

SKU: orb3177248

Description

DFCI-002-06 is an orally active dual-targeted HCK/BTK PROTAC degrader, demonstrating DC₅₀ values of 1.3 nM for HCK and 4.5 nM for BTK. It retains superior antitumor activity compared to dual-targeted HCK/BTK inhibitors and induces apoptosis in cancer cells. DFCI-002-06 is applicable in studies of MYD88-mutant B-cell malignancies.

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Key Properties

CAS Number3092208-36-8
MW794.92
FormulaC44H46N10O5
SMILESNC1=C2C(=NN(C2=NC=N1)[C@H]3CC[C@@H](CC3)N4CCN(CC5CN(C5)C=6C=C7C(=CC6)C(=O)N(C7=O)C8C(=O)NC(=O)CC8)CC4)C9=CC=C(OC%10=CC=CC=C%10)C=C9
TargetBTK,Src,PROTACs

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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DFCI-002-06 (orb3177248)

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