Dictamine

SKU: orb1301529

Description

Dictamine is a natural alkaloid with documented anticholinesterase, antimicrobial, and anti-inflammatory properties. Its cytotoxic effects against human carcinoma cell lines, such as cervical, colon, and oral cancers, make it a compound of interest for in vitro pharmacological and oncology research.

Research Area

Cell Biology, Infectious Disease & Virology

Images & Validation

−

Key Properties

−

CAS Number	484-29-7
MW	199.21
Purity	99.89% (May vary between batches)
Formula	C₁₂H₉NO₂
SMILES	COc1c2ccoc2nc2ccccc12
Target	Apoptosis,Anti-infection,Antibacterial,Antifungal
Solubility	DMSO:50 mg/mL (250.99 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (10.04 mM)

Bioactivity

−

In Vivo	Dictamnine showed different anti-inflammatory effect in variety of animal models of anti-inflammatory.
In Vitro	Dictamnine has antimicrobial activities against the model fungus Saccharomyces cerevisiae, with a minimum inhibitory concentration (MIC) value of 64 microg/ml.Dictamnine(Dic) induced S phase cell cycle arrest at low concentration and cell apoptosis at high concentration in which loss of mitochondrial membrane potential (Δψmm) was not involved. Inhibition of caspase-3 using the specific inhibitor, z-DQMD-fmk, did not attenuate Dic-induced apoptosis, implying that Dic-induced caspase-3-independent apoptosis. Combination treatment with DHA and Dic dramatically increased the apoptotic cell death compared to Dic alone. Pretreatment with z-DQMD-fmk significantly attenuated DHA and Dic co-induced apoptosis, implying that caspase-3 plays an important role in Dic and DHA co-induced cell apoptosis. Dic induced S phase cell cycle arrest at low concentration and cell apoptosis at high concentration in which mitochondria and caspase were not involved and DHA enhanced Dic induced A549 cell apoptosis via a caspase-dependent pathway. Read more...
Animal Research	High performance centrifugal partition chromatography method was used for separation of the essential dictamnine,and anti-inflammatory effects of ethanol extracts and dictamnine were investigated by xylene-induced aruical swelling in mice and the abdominal capillary permeability in mice. Read more...

Storage & Handling

−

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

Inhibitor, Fungal, inhibit, Dictamine, Dictamnine, Dectamine, Bacterial, Antiinfection, Anti-infection, Apoptosis

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID

68085 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols

Dictamine (orb1301529)

Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

No reviews yet

Dictamine

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Similar Products

Dictamine (Standard) [orb3139463]

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

Request a Document

Protocol Information

Dictamine (orb1301529)

Step 1: Enter information below

Step 2: Enter the in vivo formulation

Available Sizes

Email

UK Office

US Office

CN Office

Distributors