Diflunisal

SKU: orb1310272

Description

Diflunisal (Dolobid) is a non-steroidal anti-inflammatory drug (NSAID) that acts as a cyclooxygenase (COX) inhibitor. It is used in research for its analgesic and anti-inflammatory properties, applicable in both in vitro enzymatic assays and in vivo models of pain and inflammation.

Research Area

Epigenetics & Chromatin, Immunology & Inflammation, Neuroscience

Images & Validation

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Key Properties

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CAS Number	22494-42-4
MW	250.20
Purity	99.66% (May vary between batches)
Formula	C₁₃H₈F₂O₃
SMILES	OC(=O)c1cc(ccc1O)-c1ccc(F)cc1F
Target	Epigenetic Reader Domain,COX
Solubility	Ethanol:20 mg/mL (79.94 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.99 mM);DMSO:50 mg/mL (199.84 mM)

Bioactivity

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Target IC50	p300:996 μM
In Vivo	Diflunisal-mediated kinetic stabilization of TTR(Rate-limiting transthyretin) should ameliorate TTR amyloidoses, provided that the nonsteroidal anti-inflammatory drug liabilities can be managed clinically. Read more...
In Vitro	Diflunisal, an FDA-approved drug containing a salicylic acid substructure, inhibited CBP/p300 more potently than salicylate. Diflunisal exhibits anti-tumor activity against a specific leukemia carrying a t(8;21) translocation, a tumor previously reported to be dependent on p300 in vitro and in vivo. Read more...
Cell Research	HEK293T cells are transfected with expression vectors for WT p300 or catalitycally inactive mutant. 24 hr after transfection, cells are treated with diflunisal as indicated for 24 hr. H2B acetylation is measured by Western Blot using specified antibodies. Experiments are repeated four times. (Only for Reference) Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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p300, MK 647, MK647, MK-647, inhibit, Fluniget, EpigeneticReaderDomain, Epigenetic Reader Domain, Flovacil, Inhibitor, COX, Cyclooxygenase, Diflunisal, Dolobid, Dolobis

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Compound Identifiers

PubChem CID

3059 ↗

Key Properties

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No computed properties available.

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Diflunisal (orb1310272)

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Purity:	>98% (HPLC)
CAS Number:	22494-42-4
MW:	250.2
Formula:	C₁₃H₈F₂O₃

Diflunisal

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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