Dihydrokaempferol

SKU: orb1297460

Description

Dihydrokaempferol (Aromadendrin) is a natural flavonoid with demonstrated pro-apoptotic activity via Bcl-2/Bcl-xL downregulation. It exhibits anti-inflammatory, antioxidant, and anti-diabetic properties, supporting its research application in metabolic disease and oncology studies, both in vitro and in animal models.

Research Area

Cell Biology

Images & Validation

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Key Properties

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CAS Number	480-20-6
MW	288.25
Purity	99.96% (May vary between batches)
Formula	C₁₅H₁₂O₆
SMILES	O[C@@H]1[C@H](Oc2cc(O)cc(O)c2C1=O)c1ccc(O)cc1
Target	Bcl-2 Family,Apoptosis
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (13.88 mM);H2O:< 0.1 mg/mL (insoluble);DMSO:252.5 mg/mL (875.98 mM)

Bioactivity

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In Vitro

Aromadendrin, a flavonol, has been reported to possess a variety of pharmacological activities such as anti-inflammatory, antioxidant, and anti-diabetic properties. Aromadendrin significantly suppressed LPS-induced excessive production of pro-inflammatory mediators such as nitric oxide (NO) and PGE2. In accordance, aromadendrin attenuated LPSinduced overexpression iNOS and COX-2. In addition, aromadendrin significantly suppressed LPS-induced degradation of IκB, which sequesters NF-κB in cytoplasm, consequently inhibiting the nuclear translocation of pro-inflammatory transcription factor NF- κB. Aromadendrin significantly attenuated LPS-induced activation of JNK, but not ERK and p38, in a concentration-dependent manner. Aromadendrin exhibits anti-inflammatory activity through the suppression of nuclear translocation of NF-κB and phosphorylation of JNK in LPS-stimulated RAW 264.7 macrophage cells.

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Dihydrokaempferol, Bcl-xL, Bcl-2, Bcl-2 Family, Apoptosis, Aromadendrin, Inhibitor, inhibit, NOS, NO Synthase, PGE

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Compound Identifiers

PubChem CID

122850 ↗

Key Properties

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No computed properties available.

Protocol Information

Find More Protocols

Applications:	ELISA, WB
Reactivity:	A. thaliana
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	ELISA, WB
Reactivity:	Plant
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Purity:	99.99% (May vary between batches)
CAS Number:	572-31-6
MW:	434.39
Formula:	C₂₁H₂₂O₁₀

CAS Number:	31049-08-8
MW:	450.39
Formula:	C₂₁H₂₂O₁₁

Purity:	>98% (HPLC)
CAS Number:	31049-08-8
MW:	450.39
Formula:	C₂₁H₂₂O₁₁

Dihydrokaempferol

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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