Dihydrotanshinone I

SKU: orb1304266

Description

Dihydrotanshinone I

Research Area

Immunology & Inflammation, Infectious Disease & Virology

Images & Validation

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Key Properties

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CAS Number	87205-99-0
MW	278.30
Purity	99.59%
Formula	C₁₈H₁₄O₃
SMILES	CC1COC2=C1C(=O)C(=O)c1c2ccc2c(C)cccc12
Target	ROS,SARS-CoV
Solubility	DMSO:3.85 mg/mL (13.83 mM)

Bioactivity

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In Vivo

In ApoE-/- mice fed with an atherogenic diet, DHT (10 and 25 mg kg-1) significantly attenuated atherosclerotic plaque formation, altered serum lipid profile, decreased oxidative stress and shrunk necrotic core areas. DHT dramatically inhibits the enhanced expression of LOX-1, NOX4, and NF-κB in aorta. Dihydrotanshinone I (1, 2, 4 mg/kg) treatment can improve cardiac function, reduce infarct size, ameliorate the variations in myocardial zymogram and histopathological disorders, decrease 20-HETE generation, and regulate apoptosis-related protein in myocardial ischemia-reperfusion rats.

In Vitro

Dihydrotestosterone (DHT, 10 nM) effectively reduces the expression of lectin-like ox-LDL receptor-1 (LOX-1) and NADPH oxidase 4 (NOX4), alongside diminishing reactive oxygen species (ROS) production, nuclear translocation of NF-κB, ox-LDL endocytosis, and monocyte adhesion in lipopolysaccharide (LPS)-stimulated human umbilical vein endothelial cells (HUVECs). Additionally, Dihydrotanshinone I prompts caspase-dependent apoptosis in HCT116 cells, with this apoptosis being both concentration and ROS dependent. The presence of Z-VAD-fmk entirely prevents apoptosis, while pre-treatment with Z-LEHD-fmk significantly reduces it, and Z-IETD-fmk only achieves partial inhibition. Intriguingly, knocking down caspase-2 significantly enhances apoptosis induced by Dihydrotanshinone I.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Dihydrotanshinone I, DHTS, 15,16-dihydrotanshinone I, inhibit, Inhibitor, ROS, SARSCoV, SARS coronavirus, SARS-CoV

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Compound Identifiers

PubChem CID

5316743 ↗

Key Properties

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No computed properties available.

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