Diminazene Aceturate

SKU: orb1309619

Description

Research Area

Infectious Disease & Virology, Metabolism Research, Protein Biochemistry

Images & Validation

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Key Properties

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CAS Number	908-54-3
MW	515.52
Purity	96.86%
Formula	C₂₂H₂₉N₉O₆
SMILES	c1(ccc(cc1)/N=N/Nc1ccc(cc1)C(=N)N)C(=N)N.CC(=O)NCC(=O)O.CC(=O)NCC(=O)O
Target	Angiotensin-converting Enzyme (ACE),Serine Protease,Parasite
Solubility	H2O:92 mg/mL (178.46 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.94 mM);DMSO:1 mg/mL (1.94 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

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In Vivo

Transport of [3H] diminazene is substantially inhibited by pentamidine and adenosine, with Ki values of 0.21 μM and 0.25 μM, respectively. Notably, [3H] diminazene accumulates in yeast cells expressing TbAT1 at a rate of 0.0083 pmol/10^7 cells/s when treated with 2.5 μM of the radioactive compound, and this accumulation is completely suppressed by 1 mM of unlabeled Diminazene Aceturate.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Parasite, inhibit, Inhibitor, DIZE, Diminazene, Diminazene Aceturate, Diminazene diaceturate, Angiotensin-converting Enzyme (ACE), QacR, SerineProtease, Serine Protease, Peroxiredoxin-5, Trypsin-1

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Compound Identifiers

PubChem CID

5284544 ↗

Key Properties

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No computed properties available.

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