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Dodecane

SKU: orb2279169

Description

Dodecane is a linear alkane solvent and fuel component, also employed as a reference standard. In research, it serves as a model irritant in dermatological studies, where it has been shown to induce TNF-α expression in rat skin in vivo.

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number112-40-3
MW170.33
FormulaC12H26
SMILESCCCCCCCCCCCC
TargetOthers,TNF
SolubilityDMSO:15 mg/mL (88.06 mM)

Bioactivity

In Vivo
Methods: Hairless rats (CD HrBi rats) were treated with dodecane (230 μL, topical, single dose, 1 hour) to investigate the effects of dodecane on skin irritation (erythema), transepidermal water loss (TEWL), and expression of interleukin-1α (IL-1α), tumor necrosis factor (TNF-α), and monocyte chemoattractant protein-1 (MCP-1) in the skin and blood. Results: Dodecane induced high transepidermal water loss and increased TNF-α expression in the CD HrBi rat model.

Storage & Handling

StoragePure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Ba 51-090453, Dodecane

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Key Properties

No computed properties available.

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Dodecane (orb2279169)

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1 ml
$ 130.00
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