Dryocrassin ABBA

SKU: orb1220214

Description

Dryocrassin ABBA (Dryocrassin) is a flavonoid natural product derived from Dryopteris crassirhizoma, with antiviral and antibacterial activities. Dryocrassin ABBA exhibits antiviral activity against H5N1 avian influenza virus. Dryocrassin ABBA inhibits the coagulase activity of Staphylococcus aureus vWbp. Dryocrassin ABBA suppresses immunostimulatory function of dendritic cells and prolongs skin allograft survival.

Images & Validation

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Key Properties

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CAS Number	12777-70-7
MW	820.83
Purity	>98% (HPLC)
Formula	C??H??O??
SMILES	OC1=C(C(O)=C(C(CCC)=O)C(O)=C1CC(C(C(C(C)=O)=C(O)C2(C)C)=O)=C2O)CC(C(O)=C(C(CCC)=O)C(O)=C3CC(C(C(C(C)=O)=C(O)C4(C)C)=O)=C4O)=C3O
Target	Influenza Virus
Solubility	In Vitro: DMSO : 16.67 mg/mL (20.31 mM)

Bioactivity

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In Vivo

Dryocrassin ABBA (Dryocrassin) (0-33 mg/kg; i. g. ; daily, 7 days from day 2 to day 8) exerts a significant dose-dependent antiviral effect in mice. Dryocrassin ABBA (100 mg/kg; s. c. ; every 12 h for 96 h) can reduce infection and prevent mice from contracting S. aureus pneumonia. Animal model: SPF BALB/C female mice inoculated intra-nasally with 104.5ELD50 H5N1 viruses in 100 μl saline. Dosage: 33, 18, and 12.5 mg/kg. Administration: Oral gavage, daily, 7 days from day 2 to day 8. Result: Significantly reduced mortality, prolonged survival rate, and improved survival time throughout the infection period. Increased body weight and reduced lung lesions and virus loads. Significantly increased MCP-1 and IL-10 while significantly decreased IL-12, IL-6, IFN-γ and TNF-α. Animal model: Eight-week-old C57BL/6J mice infected with 30 μL of S. aureus Newman (2 × 108 CFU/10 μL) by intranasal administration. Dosage: 100 mg/kg. Administration: Subcutaneous injection, every 12 h for 96 h. Result: Resulted a significant increase in survival.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Influenza Virus

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