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DT2216

SKU: orb691969

Description

DT2216 is a selective B-cell lymphoma extra large (BCL-XL) proteolysis-targeting chimera (PROTAC). DT2216 targets BCL-XL to the Von Hippel-Lindau (VHL) E3 ligase for degradation. DT2216 inhibits various BCL-XL-dependent leukemia and cancer cells but considerably less toxic to platelets.

Images & Validation

Key Properties

CAS Number2365172-42-3
MW1542.36
Purity>98%
FormulaC77H96ClF3N10O10S4
SMILESCC1(CC(CN2CCN(C3C=CC(C(=O)NS(=O)(C4C=CC(N[C@H](CCN5CCN(C(=O)CCCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)N[C@@H](C)C6C=CC(C7SC=NC=7C)=CC=6)C(C)(C)C)CC5)CSC5C=CC=CC=5)=C(S(=O)(=O)C(F)(F)F)C=4)=O)=CC=3)CC2)=C(C2C=CC(Cl)=CC=2)CC1)C

Storage & Handling

Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

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Protocol Information

DT2216 (orb691969)

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100 mg
$ 2,370.00
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