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DTHIB

SKU: orb1298577

Description

DTHIB is a potent small molecule inhibitor of HSF1 signaling. It robustly suppresses the HSF1-driven oncogenic transcriptional program and inhibits the proliferation of prostate cancer cells in vitro. This compound is a valuable research tool for investigating HSF1 pathway biology and cancer therapeutics.

Research Area

Metabolism Research, Signal Transduction

Images & Validation

Key Properties

CAS Number897326-30-6
MW309.68
Purity99.69% (May vary between batches)
FormulaC13H9ClFN3O3
SMILES[O-][N+](=O)c1cc(NC(=O)Nc2ccc(F)cc2)ccc1Cl
TargetHSP
Solubility10% DMSO+90% Saline:2 mg/mL (6.46 mM);DMSO:25 mg/mL (80.73 mM)

Bioactivity

Target IC50
DTHIB binding to the HSF1 DNA binding domain:160 nM (Kd)

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

cancer, anticancer, degradation, DTHIB, HSP, HSP70, HSP90, HSP27, HSF1, Heat shock proteins, nuclear, inhibit, Inhibitor, prostate

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  • DTHIB [orb1217517]

    >98% (HPLC)

    897326-30-6

    309.68

    C13H9ClFN3O3

    5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 2 mg, 1 g, 500 mg
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Key Properties

No computed properties available.

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Protocol Information

DTHIB (orb1298577)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 70.00
5 mg
$ 110.00
1 ml x 10 mM (in DMSO)
$ 120.00
10 mg
$ 150.00
25 mg
$ 270.00
50 mg
$ 400.00
100 mg
$ 610.00
500 mg
$ 1,230.00
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