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Duostatin 5

SKU: orb1944690

Description

Duostatin 5 (Duo-5) is a synthetic analog of the natural dolastatin 10 toxin, designed for constructing antibody-drug conjugates (ADCs). It serves as a potent microtubule-disrupting payload in oncology research, enabling the evaluation of targeted therapies in both cellular and animal models.

Images & Validation

Key Properties

CAS Number2124210-34-8
MW772.03
Purity99.56% (May vary between batches)
FormulaC40H69N9O6
SMILES[C@H]([C@H](C(N[C@@H](CC1=CC=C(N)C=C1)CN=[N+]=[N-])=O)C)(OC)[C@]2(N(C(C[C@H]([C@@H](N(C([C@@H](NC([C@H](C(C)C)N(C)C)=O)[C@@H](C)C)=O)C)[C@H](CC)C)OC)=O)CCC2)[H]
TargetADC Cytotoxin
SolubilityDMSO:100 mg/mL (129.53 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (5.18 mM)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

ADCCytotoxin, ADC Cytotoxin, Antibody-Drug Conjugates (ADCs)

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 100.00
5 mg
$ 170.00
1 ml x 10 mM (in DMSO)
$ 200.00
10 mg
$ 220.00
25 mg
$ 390.00
50 mg
$ 630.00
100 mg
$ 990.00
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