Dupilumab Antibody

SKU: orb1707978

Description

Dupilumab (REGN-668) is a fully human monoclonal antibody targeting the IL-4 receptor alpha subunit, thereby blocking IL-4 and IL-13 signaling. It is widely used in research models of atopic dermatitis and other type 2 inflammatory diseases to investigate therapeutic mechanisms in both in vitro and in vivo settings.

Research Area

Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number	1190264-60-8
MW	149.8 kDa
Purity	98% by SEC-HPLC
Target	IL Receptor,Interleukin

Bioactivity

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Target IC50	IL-4Rα (monomeric):33 pM (KD)\|IL-4Rα (dimeric):12 pM (KD)
In Vivo	In human whole blood, dupilumab inhibits IL-4 and il-13 to stimulate thymus secretion and activates chemokine/chemokine C motif ligand 17 (TARC/CCL17). (Clinical biomarker for atopic dermatitis) with yarnamore potency (50% inhibition at 0.24 to 0.52 nM and 0.26 to 0.27 nM). Read more...
In Vitro	Dupilumab inhibited mRNA expression of T cells, dc, eosinophils, inflammatory pathways and Th2-induced chemokine activation related genes in skin lesions, and showed no activity against IL-17A and significantly decreased IL-22 levels, but 300 mg Dupilumab significantly decreased the expression of IL-17-related genes. Such as elafin (PI3), IL23p19/IL23A and S100A8, and have inhibitory potential (CXCL1 and S100A7). Dupilumab (300 mg) inhibited hyperproliferation-related genes, such as K16, and decreased the expression of S100A, as measured by microarray and qRT-PCR. Read more...

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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REGN668, REGN-668, REGN 668, SAR231893, SAR-231893, SAR 231893, Dupilumab, IL Receptor, ILReceptor, IL-4, IL-13

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Gene Symbol

IL Receptor,Interleukin

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