(E)-[6]-Dehydroparadol

SKU: orb1708139

Description

(E)-[6]-Dehydroparadol is a bioactive oxidative metabolite of [6]-Shogaol, recognized as a potent activator of the Nrf2 pathway. This small molecule is utilized in research to study antioxidant response mechanisms in both cellular and animal models of oxidative stress.

Research Area

Cell Biology, Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number	878006-06-5
MW	276.37
Purity	99.87% (May vary between batches)
Formula	C₁₇H₂₄O₃
SMILES	CCCCCCCC(=O)\C=C\c1ccc(O)c(OC)c1
Target	Nrf2,Apoptosis
Solubility	DMSO:120 mg/mL (434.2 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (14.47 mM)

Bioactivity

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Target IC50	HCT116 cells:41.59 μM \|HCT116 cells:43.02 μM
In Vivo	(E)--Dehydroparadol at a concentration of 5 µM for 24 hours increases the fluorescence signal of Tg[glutathione S-transferase pi 1 (gstp1):green fluorescent protein (GFP)] in Tg(gstp1:GFP) transgenic zebrafish embryos. Read more...
In Vitro	(E)--Dehydroparadol (5-80 µM; 24 h) inhibits the growth of HCT-116 and H-1299 cells, with IC50s of 43.02 and 41.59 µM, respectively. (E)--Dehydroparadol (10-40 µM; 24 h) induces apoptosis in HCT-116 and H-1299 cells. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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[6]-Dehydroparadol, (6)-Dehydroparadol, HCT-116, Nrf2

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Compound Identifiers

PubChem CID

6438480 ↗

Key Properties

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No computed properties available.

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