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EBI-907

SKU: orb1739056

Description

EBI-907 is a potent, orally bioavailable B-RafV600E inhibitor with single-digit nanomolar IC50 (4.9 nM), demonstrating >10-fold greater potency than Vemurafenib in cellular assays. It effectively inhibits proliferation and Erk phosphorylation in BRAF(V600E)-dependent cell lines and shows activity against other kinases like BRK and FGFR1, supporting its use in oncology research for in vitro and in vivo studies.

Research Area

Signal Transduction

Images & Validation

Key Properties

CAS Number1581764-31-9
MW506.95
FormulaC23H21ClF2N4O3S
SMILESO(C)C1=CC2=C3C(=NN=C3NC=C2C=C1C4=C(Cl)C(NS(CCCF)(=O)=O)=CC=C4F)C5CC5
TargetRaf,Others

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Key Properties

No computed properties available.

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Protocol Information

EBI-907 (orb1739056)

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