Ecteinascidin 770

SKU: orb1709800

Description

Ecteinascidin 770 is a small molecule that inhibits RNA-dependent RNA polymerase 1 (RDRP1), demonstrating antiviral activity against SARS-CoV-2 and antibacterial effects against Mycobacterium tuberculosis in vitro. Its primary research application is in oncology for studying cancer cell viability mechanisms.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology

Images & Validation

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Key Properties

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CAS Number	114899-80-8
MW	770.85
Purity	99.84% (May vary between batches)
Formula	C₄₀H₄₂N₄O₁₀S
SMILES	C(#N)[C@@H]1N2[C@@]([C@]3(C=4C([C@@]2(COC(=O)[C@@]5(CS3)C=6C(=CC(O)=C(OC)C6)CCN5)[H])=C7C(=C(C)C4OC(C)=O)OCO7)[H])([C@]8(C=9C(C[C@@]1(N8C)[H])=CC(C)=C(OC)C9O)[H])[H]
Target	Antibacterial,Apoptosis,DNA/RNA Synthesis,SARS-CoV
Solubility	DMSO:40 mg/mL (51.89 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.59 mM)

Bioactivity

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Target IC50	DU-145 cells:0.81 nM\|U-373MG cells:4.83 nM\|HCT116 cells:0.6 nM
In Vitro	Methods: U373MG glioblastoma cells were treated with Ecteinascidin 770, and cytotoxicity was detected by MTT assay. Results: The IC 50 value of Ecteinascidin 770 against U373MG cells was 4.83 nM. Read more...

Storage & Handling

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Storage	keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Ecteinascidin 770, Ecteinascidine 770, Et770, Et-770, U373MG cell

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID

10952807 ↗

Key Properties

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No computed properties available.

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