EHMT1 (C) Antibody, Rabbit Polyclonal

SKU: orb66842

Description

Rabbit polyclonal to EHMT1.EHMT1 is a Histone-lysine N-methyltransferase that specifically mono-and dimethylates 'Lys-9' ofhistone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tagfor epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. EHMT1also weakly methylates 'Lys-27' of histone H3 (H3K27me). EHMTa is also required for DNAmethylation independent of its histone methyltransferase. During G0 phase, EHMT1 contributes tosilencing of MYC-and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. Inaddition to the histone methyltransferase activity, EHMT1 also methylates non-histone proteins, suchas the dimethylation of 'Lys-373' of p53/TP53.

Research Area

Epigenetics

Images & Validation

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Tested Applications	WB
Dilution Range	WB:1:1000-1:5000
Reactivity	Human

Key Properties

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Host	Rabbit
Clonality	Polyclonal
Immunogen	C-terminal region of human EHMT1
Molecular Weight	141
Purity	Affinity purification
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Buffer/Preservatives	0.01% NaN3
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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anti-EHMT1 antibody,anti-Histonelysine Nmethyltransferase antibody,anti-Euchromatic histonelysine Nmethyltransferase 1 antibody,anti-G9alike protein 1 antibody,anti-Histone H3K9 methyltransferase 5 antibody,anti-H3K9HMTase 5 antibody,anti-Lysine Nmethyltransferase 1D antibody,anti- EUHMTASE1 antibody,anti-GLP antibody,anti-KIAA1876 antibody,anti-KMT1D antibody

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Western blot analysis of total cell extracts from human Hela using EHMT1 antibody

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UniProt

Q9H9B1

UniProt Details

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No UniProt data available

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Protocol Information

Western Blot (IB, immunoblot)

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