Elezanumab Antibody

SKU: orb1980581

Description

Elezanumab (ABT-555) is a high-affinity human monoclonal antibody targeting RGMa, potently inhibiting RGMa-mediated BMP/SMAD1/5/8 signaling. It has demonstrated neuroprotective and axonal regenerative effects in preclinical models of spinal cord injury and demyelination, promoting corticospinal tract sprouting and serotonergic innervation.

Research Area

Neuroscience, Stem Cell & Developmental Biology

Images & Validation

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Key Properties

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Antibody Type	Inhibitor Antibody
Clonality	Monoclonal
Target	RGM,TGF-beta/Smad
Molecular Weight	143.43 kDa
Purity	97.20% (May vary between batches)
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Concentration	4.65 mg/mL
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Elezanumab, ABT 555, ABT555, ABT-555, AE12-1Y-QL, TGFβ, TGF-β/Smad, TGFb, TGF-b/Smad, TGFbeta, TGF-beta, TGFbeta/Smad, TGF-beta/Smad, Smad

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Gene Symbol

RGM,TGF-beta/Smad

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