Cart summary

You have no items in your shopping cart.

Emprumapimod

SKU: orb1686974

Description

Emprumapimod (PF-07265803) is a selective, orally bioavailable p38α MAPK inhibitor that suppresses LPS-induced IL-6 production. It serves as a valuable research tool for investigating mechanisms and potential treatments for LMNA-related dilated cardiomyopathy in both cellular and animal models.

Research Area

Signal Transduction

Images & Validation

Key Properties

CAS Number765914-60-1
MW473.52
Purity99.21%
FormulaC24H29F2N5O3
SMILESC(C(C)C)N1C=2C(=CC(OC3=C(F)C=C(F)C=C3)=C(C(N[C@@H](CCN(C)C)C(N)=O)=O)C2)C=N1
Targetp38 MAPK
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.97 mM);DMSO:80 mg/mL (168.95 mM)

Bioactivity

In Vivo
In LmnaH222P/H222P mice, Emprumapimod (30 mg/kg; administered orally by gavage; starting at 16 weeks of age and continuing until 20 weeks of age) significantly increased left ventricular end-diastolic diameter (LVEDD) and left ventricular end-systolic diameter (LVESD), while reducing FS, a parameter directly proportional to the left ventricular ejection fraction.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

ARRY-371797, p38MAPK, p38 MAPK, PF-07265803
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

Emprumapimod (orb1686974)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 310.00
5 mg
$ 580.00
10 mg
$ 900.00
25 mg
$ 1,320.00
DispatchUsually dispatched within 5-10 working days
Bulk Enquiry