Enalapril

SKU: orb1224056

Description

Enalapril is an angiotensin converting enzyme (ACE) inhibitor Target: ACE Enalapril belongs to a class of medications called angiotensin converting enzyme inhibitors. Normally angiotensin I is converted to angiotensin II by angiotensin converting enzyme (ACE).

Images & Validation

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Key Properties

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CAS Number	75847-73-3
MW	376.45
Purity	>98% (HPLC)
Formula	C₂₀H₂₈N₂O₅
SMILES	O=C(O)[C@H]1N(C([C@H](C)N[C@H](C(OCC)=O)CCC2=CC=CC=C2)=O)CCC1
Target	ACE
Solubility	soluble in Water

Bioactivity

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In Vivo

Enalapril (intraperitoneal injection, 0.03 mg/kg, once, 1 hour) reduces infarct volume due to middle cerebral artery occlusion and lower or higher doses are ineffective in Male NMRI mice. Animal model: Male NMRI mice 20-40 g. Dosage: 0.03 mg/kg. Administration: Intraperitoneal injection; once. Result: Reduced the area of middle cerebral artery infarction in mice at 0.03 mg/kg.

In Vitro

Enalapril (10-20 μM) has an antiarrhythmic effect in ultrafiltered PV sleeve preparation isolated from canine hearts which can inhibit EAD and DAD-induced activity. Enalapril (50 μM, 24 hours) inhibits the induction of apoptosis by patient serum only when used prior to treatment of HUVEC with Alzheimer's disease (AD) serum. Pure Enalapril has better thermal stability than pure Enalapril. TApoptosis Analysis Cell line: Human umbilical vein ECs (HUVECs). Concentration: 50 μM. Incubation time: 24 hours. Result: Inhibited the induction of apoptosis by patient serum.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Enalapril | Gadopril | Kinfil | Bonuten

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ACE

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Enalapril (orb1224056)

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CAS Number:	149404-21-7
MW:	399.443
Formula:	C₂₀H₂₈N₂NaO₅

Purity:	99.51% (May vary between batches)
CAS Number:	75847-73-3
MW:	376.45
Formula:	C₂₀H₂₈N₂O₅

Purity:	97.28% (May vary between batches)
CAS Number:	76420-72-9
MW:	348.39
Formula:	C₁₈H₂₄N₂O₅

CAS Number:	1356922-29-6
MW:	375.41
Formula:	C₁₈H₁₈D₅N₂NaO₅

CAS Number:	76095-16-4
MW:	492.52
Formula:	C₂₀H₂₈N₂O₅·C₄H₄O₄

Enalapril

Description

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Enalapril (orb1224056)

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