Enalaprilat Dihydrate

SKU: orb1223873

Description

Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM.(In Vitro):Enalaprilat (1 nM-10 μM; 24 h) dihydrate attenuates the IGF-I induced neonatal rat cardiac fibroblast growth (30% reduction) in a concentration-dependent fashion, with an IC50 of 90 mM.(In Vivo):Enalaprilat (0.01%-2.9% in the eyedrop solution) dihydrate shows significant intraocular pressure (IOP)-lowering effect in rabbits.

Images & Validation

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Key Properties

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CAS Number	84680-54-6
MW	348.4
Purity	>98% (HPLC)
Formula	C₁₈H₂₄N₂O₅.2H₂O
SMILES	O.O.C[C@H](N[C@@H](CCC1=CC=CC=C1)C(O)=O)C(=O)N1CCC[C@H]1C(O)=O \|r,c:8,10,t:6\|
Target	RAAS
Solubility	DMSO:70 mg/mL (200.91 mM)； Ethanol:<1 mg/mL (<1 mM)； Water:<1 mg/mL (<1 mM)

Bioactivity

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In Vivo	Enalaprilat (0.01%-2.9% in the eyedrop solution) dihydrate shows significant intraocular pressure (IOP)-lowering effect in rabbits.
In Vitro	Enalaprilat (1 nM-10 μM; 24 h) dihydrate attenuates the IGF-I induced neonatal rat cardiac fibroblast growth (30% reduction) in a concentration-dependent fashion, with an IC50 of 90 mM. Read more...

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

RAAS

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