Enciprazine dihydrochloride

Enciprazine dihydrochloride is an orally active non-benzodiazepine anxiolytic agent. It functions as a 5-HT1A receptor (5-HT1AR) agonist and an α1-adrenergic receptor antagonist. This compound induces changes in drug-induced EEG by decreasing the average power of δ and θ waves while increasing the average power of α and fast β waves. Enciprazine dihydrochloride exhibits anti-aggressive activity with only mild sedative and ataxic effects. It modulates plasma corticosterone levels and activates the hypothalamic-pituitary-adrenal axis. Enciprazine dihydrochloride is applicable in studies related to anxiety disorders, generalized anxiety syndrome, and psychotic conditions.