(-)-Epigallocatechin-3-(3''-O-methyl) gallate

SKU: orb1684629

Description

(-)-EGCG-3''-O-ME is a methylated catechin from tea, exhibiting potent antioxidant, cytotoxic, and antibacterial properties. Its application in dental research includes enhancing dentin adhesive stability. Studies investigate its bioactivity in vitro for potential chemopreventive and antimicrobial roles.

Research Area

Infectious Disease & Virology, Metabolism Research

Images & Validation

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Key Properties

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CAS Number	83104-87-4
MW	472.4
Purity	99.59% (May vary between batches)
Formula	C₂₃H₂₀O₁₁
SMILES	O(C(=O)C1=CC(OC)=C(O)C(O)=C1)[C@H]2[C@H](OC=3C(C2)=C(O)C=C(O)C3)C4=CC(O)=C(O)C(O)=C4
Target	Antioxidant,Antibacterial

Bioactivity

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Target IC50

α-amylase:0.54 mg/mL|COX-2:0.17 ± 0.03 μM|DPPH-derived radicals:36.54 μM|ABTS radicals:2.59 μM

In Vitro

(-)-Epigallocatechin-3-(3''-O-methyl) gallate (3″Me-EGCG) (0–12.5 μM; 30 min; 37 °C) demonstrated scavenging effects in both HaCaT cell and cell-free systems. 3″Me-EGCG (6.25、12.5 μM) increased cell viability and heme oxygenase 1 (HO-1) expression under H2O2 exposure and protected keratinocytes while regulating the survival protein AKT1 under ultraviolet B (UVB) and sodium nitroprusside (SNP) exposure.

Storage & Handling

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Storage	store at low temperature,keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Bacterial, Antioxidant, (-)-EGCG-3''-O-ME, Immunology & Inflammation related, Epigallocatechin-3-(3''-O-methyl) gallate, EGCG-3''-O-ME

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Compound Identifiers

PubChem CID

9804842 ↗

Key Properties

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No computed properties available.

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