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Epimagnolin A

SKU: orb1297384

Description

Epimagnolin A is a bioactive lignan isolated from Magnolia fargesii flower buds. Research indicates it exhibits anti-inflammatory and neuroprotective properties in vitro, supporting its investigation for applications in neurological and inflammatory disease research.

Research Area

Infectious Disease & Virology

Images & Validation

Key Properties

CAS Number41689-51-4
MW416.46
Purity99.82%
FormulaC23H28O7
SMILES[H][C@]12CO[C@@H](c3cc(OC)c(OC)c(OC)c3)[C@@]1([H])CO[C@@H]2c1ccc(OC)c(OC)c1
TargetParasite
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.8 mM);DMSO:12 mg/mL (28.81 mM)

Bioactivity

In Vitro
A herbal compound fargesin obtained from M. fargesii, has exerted anti-inflammatory effects in human monocytic THP-1 cells in the previous study. it was demonstrated that epimagnolin A reduced phorbol-12-myristate-13-acetate (PMA)-induced IL-6 promoter activity and IL-6 production in human monocytic THP-1 cells. Furthermore, it was investigated the modulating effects of epimagnolin A on mitogen-activated protein kinase, nuclear factor-kappa B (NF-κB), and activator protein 1 (AP-1) activities. Phosphorylation of p38 and nuclear translocation of p50 and c-Jun were down-regulated by epimagnolin A in the PMA-stimulated THP-1 cell. The results revealed that epimagnolin A attenuated the binding affinity of NF-κB and AP-1 transcription factors to IL-6 promoter and IL-6 production through p38/NF-kB and AP-1 signaling pathways in the PMA-stimulated THP-1 cells. These results suggest that epimagnolin A can be a useful drug for the treatment of inflammatory diseases.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

ABCB1, antiplasmodial, ATPase, Parasite, lignan, inhibit, Epimagnolin A, furfuran, Inhibitor

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Key Properties

No computed properties available.

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Epimagnolin A (orb1297384)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 160.00
2 mg
$ 210.00
5 mg
$ 340.00
1 ml x 10 mM (in DMSO)
$ 380.00
10 mg
$ 490.00
25 mg
$ 760.00
50 mg
$ 1,030.00
100 mg
$ 1,370.00
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