Erzotabart Antibody

SKU: orb1942326

Description

Erzotabart is an investigational IgG1-kappa monoclonal antibody targeting human CD38. Its antineoplastic activity, demonstrated in preclinical studies, stems from disrupting CD38-mediated pathways crucial for tumor cell proliferation, metabolism, and immune evasion in oncology research.

Research Area

Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number	2430792-01-9
MW	145.01 kDa
Purity	95.00%
Target	CD38

Bioactivity

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In Vivo

Methods: Administer Erzotabart (10 mg/kg, once weekly for 3 weeks) intravenously to the patient-derived Parazacco spilurus subsp. spilurus xenograft (PDX) mouse models to evaluate the anti-tumor activity of HexaBody-CD38. Results: Erzotabart demonstrated significant anti-tumor activity in both B-cell non-Hodgkin lymphoma (B-NHL) and acute myeloid leukemia (AML) models, with its efficacy closely correlated to CD38 expression levels .

In Vitro

Erzotabart targets the cell surface glycoprotein CD38 and carries the E430G mutation itself. This mutation is located in its Fc fragment, which promotes antibody hexamer formation, thereby endowing Erzotabart with immunomodulatory and anti-tumor activities . At the functional level, Erzotabart can induce complement-dependent cytotoxicity (CDC), antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and phagocytosis. It also inhibits CD38 cyclase activity while enhancing hydrolase activity, with corresponding half-maximal effective concentrations (EC₅₀) of 0.044 µg/mL, 0.29 ng/mL, 2.719–5.779 ng/mL, 8.79 ng/mL, 0.419 µg/mL, and 0.335 µg/mL, respectively .

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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GEN 3014, GEN3014

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Gene Symbol

CD38

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